Understanding the functional discrepancy of Pim-1 in cancer.

نویسندگان

  • Allal Ouhtit
  • Sukalp Muzumdar
  • Ishita Gupta
  • Somya Shanmuganathan
  • Yahya Tamimi
چکیده

The Pim-1 gene encodes for a proto-oncogenic serine/threonine protein kinase and is generally involved in cytokine signaling as well as in various signaling pathways regulating cell cycle and apoptosis. Pim-1 kinase plays a role in the development of various tumors mainly, prostate cancer, Burkitt's lymphoma, oral cancer and various other hematopoietic lymphomas. This review will focus on the importance and mechanisms of Pim-1 in prostate cancer and the potential clinical relevance of its various inhibitors.

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عنوان ژورنال:
  • Frontiers in bioscience

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2015